Metabolic route computation in organism communities

Abstract Background Microbiomes are complex kiara sky peach sangria aggregates of organisms, each of which has its own extensive metabolic network.A variety of metabolites are exchanged between the microbes.The challenge we address is understanding the overall metabolic capabilities of a microbiome: through what series of metabolic transformations

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The DNMT3A PWWP domain is essential for the normal DNA methylation landscape in mouse somatic cells and oocytes.

DNA methylation at CG sites is important for gene regulation and embryonic development.In mouse oocytes, de novo CG methylation requires preceding transcription-coupled histone mark H3K36me3 and is mediated by a DNA methyltransferase DNMT3A.DNMT3A has a PWWP domain, which recognizes H3K36me2/3, and heterozygous mutations in this domain, including D

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